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Article

Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection

8 Dec 2019

Abstract excerpt

BACKGROUNDRespiratory syncytial virus (RSV) is an important cause of acute pulmonary disease and one of the last remaining major infections of childhood for which there is no vaccine. CD4+ T cells play a key role in antiviral immunity, but they have been little studied in the human lung.METHODSHealthy adult volunteers were inoculated i.n. with RSV A Memphis 37. CD4+ T cells in blood and the lower airway were...

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PMID: 31815739
DOI: 10.1172/jci131696

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