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Article

Single-cell profiling demonstrates the combined effect of wheeze phenotype and infant viral infection on airway epithelial development.

Science advances - 23 May 2025

Berdnikovs Sergejs, Newcomb Dawn C, Haruna Nana-Fatima, McKernan Kaitlin E, Kuehnle Shelby N, Gebretsadik Tebeb, McKennan Christopher, Ma Siyuan, Cephus Jacqueline-Yvonne, Rosas-Salazar Christian, Anderson Larry J, Gern James E, Hartert Tina

Abstract excerpt

The development of the airway epithelium in asthma is unclear. We characterized nasal airway epithelial cell (NAEC) developmental phenotypes from children aged 2 to 3 years in an a priori designed nested birth cohort from four mutually exclusive groups of wheezers/nonwheezers and respiratory syncytial virus (RSV)-infected/uninfected in the first year of life. NAECs were differentiated, followed by single-cell RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40408478
DOI: 10.1126/sciadv.adr9995
PMCID: PMC12101503

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