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Article

Impaired melanocortin pathway function in Prader–Willi syndrome gene-Magel2 deficient mice

1 Jun 2018

Abstract excerpt

Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with several genes, including MAGEL2, which is abundantly expressed in the hypothalamus. Of appetite regulating hypothalamic cell types, both AGRP and POMC-expressing neurons contain Magel2...

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PMID: 29878108
DOI: 10.1093/hmg/ddy216

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