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Article

Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.

Endocrinology - 1 Mar 2012

Padilla Stephanie L, Reef Daniel, Zeltser Lori M

Abstract excerpt

Melanocortin signaling plays a central role in the regulation of phenotypes related to body weight and energy homeostasis. To specifically target and study the function of proopiomelanocortin (POMC) neurons, Pomc promoter elements have been utilized to generate reporter and Cre recombinase transg...

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Source

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Identifiers

PMID: 22166984
DOI: 10.1210/en.2011-1665
PMCID: PMC3281533

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22166984-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.PMID 22166984Read ↗

Various transgenic mouse lines to study proopiomelanocortin cells in the brain stem label disparate populations of GABAergic and glutamatergic neurons.Semantic proximity Read ↗

Age-dependent changes in amino acid phenotype and the role of glutamate release from hypothalamic proopiomelanocortin neurons.Semantic proximity Read ↗

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.Semantic proximity Read ↗

Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic FootprintingSemantic proximity Read ↗

Expression of GABAergic and glutamatergic phenotypic markers in hypothalamic proopiomelanocortin neurons.Semantic proximity Read ↗

Functional heterogeneity of POMC neurons relies on mTORC1 signaling.Semantic proximity Read ↗

60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expressionSemantic proximity Read ↗

Caloric restriction selectively reduces the GABAergic phenotype of mouse hypothalamic proopiomelanocortin neurons.Semantic proximity Read ↗

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthoodSemantic proximity Read ↗

Impaired melanocortin pathway function in Prader–Willi syndrome gene-Magel2 deficient miceSemantic proximity Read ↗

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy.Semantic proximity Read ↗

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.Semantic proximity Read ↗

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