Article
A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts.
Oncotarget - 13 Sept 2016
El-Hoss Jad, Jing Duohui, Evans Kathryn, Toscan Cara, Xie Jinhan, Lee Hyunjoo, Taylor Renea A, Lawrence Mitchell G, Risbridger Gail P, MacKenzie Karen L, Sutton Rosemary, Lock Richard B
Abstract excerpt
Patient derived xenografts (PDXs) have become a vital, frequently used, component of anti-cancer drug development. PDXs can be serially passaged in vivo for years, and shared across laboratories. As a consequence, the potential for mis-identification and cross-contamination is possible, yet authentication of PDXs appears limited. We present a PDX Authentication System (PAS), by combining a commercially available...
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