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Article

A novel RNA sequencing data analysis method for cell line authentication.

PloS one - 1 Jan 2017

Fasterius Erik, Raso Cinzia, Kennedy Susan, Rauch Nora, Lundin Pär, Kolch Walter, Uhlén Mathias, Al-Khalili Szigyarto Cristina

Abstract excerpt

We have developed a novel analysis method that can interrogate the authenticity of biological samples used for generation of transcriptome profiles in public data repositories. The method uses RNA sequencing information to reveal mutations in expressed transcripts and subsequently confirms the identity of analysed cells by comparison with publicly available cell-specific mutational profiles. Cell lines constitute...

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PMID: 28192450
DOI: 10.1371/journal.pone.0171435
PMCID: PMC5305277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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