Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.

Diabetes care - 1 Nov 2016

Shah Hetal S, Gao He, Morieri Mario Luca, Skupien Jan, Marvel Skylar, Paré Guillaume, Mannino Gaia C, Buranasupkajorn Patinut, Mendonca Christine, Hastings Timothy, Marcovina Santica M, Sigal Ronald J, Gerstein Hertzel C, Wagner Michael J, Motsinger-Reif Alison A, Buse John B, Kraft Peter, Mychaleckyj Josyf C, Doria Alessandro

Abstract excerpt

OBJECTIVE: To identify genetic determinants of increased cardiovascular mortality among subjects with type 2 diabetes who underwent intensive glycemic therapy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS: A total of 6.8 million common variants were analyzed for genome-wide association with cardiovascular mortality among 2,667 self-reported white subjects in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Diabetes Mellitus, Type 2

Share to Glycated Hemoglobin

Share to Hypoglycemic Agents

Share to Proportional Hazards Models

Share to Randomized Controlled Trials as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 27527847
DOI: 10.2337/dc16-0285
PMCID: PMC5079609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.PMID 27527847Read ↗

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.Semantic proximity Read ↗

A Type 2 Diabetes Subtype Responsive to ACCORD Intensive Glycemia TreatmentSemantic proximity Read ↗

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial.Semantic proximity Read ↗

Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.Semantic proximity Read ↗

Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study.Semantic proximity Read ↗

Polygenic risk scores predict diabetic complications and their response to therapySemantic proximity Read ↗

Haptoglobin Phenotype Modifies the Influence of Intensive Glycemic Control on Cardiovascular Outcomes.Semantic proximity Read ↗

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.Semantic proximity Read ↗

Haptoglobin Phenotype and Intensive Glycemic Control for Coronary Artery Disease Risk Reduction in People With Type 2 Diabetes: The ADVANCE Study.Semantic proximity Read ↗

Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease.Semantic proximity Read ↗

Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine.Semantic proximity Read ↗

Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.