Article
Cluster Analysis of Cardiovascular Phenotypes in Patients With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease: A Potential Approach to Precision Medicine.
Diabetes care - 1 Jan 2022
Sharma Abhinav, Zheng Yinggan, Ezekowitz Justin A, Westerhout Cynthia M, Udell Jacob A, Goodman Shaun G, Armstrong Paul W, Buse John B, Green Jennifer B, Josse Robert G, Kaufman Keith D, McGuire Darren K, Ambrosio Giuseppe, Chuang Lee-Ming, Lopes Renato D, Peterson Eric D, Holman Rury R
Abstract excerpt
OBJECTIVE: Phenotypic heterogeneity among patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) is ill defined. We used cluster analysis machine-learning algorithms to identify phenotypes among trial participants with T2DM and ASCVD. RESEARCH DESIGN AND METHODS: We used data from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study (n = 14,671), a...
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