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Article

Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish.

Journal of pediatric gastroenterology and nutrition - 1 Nov 2016

Tang Vivian, Cofer Zenobia C, Cui Shuang, Sapp Valerie, Loomes Kathleen M, Matthews Randolph P

Abstract excerpt

OBJECTIVES: Biliary atresia (BA) is a progressive fibroinflammatory cholangiopathy affecting the bile ducts of neonates. Although BA is the leading indication for pediatric liver transplantation, the etiology remains elusive. Adducin 3 (ADD3) and X-prolyl aminopeptidase 1 (XPNPEP1) are 2 genes previously identified in genome-wide association studies as potential BA susceptibility genes. Using zebrafish, we...

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Source

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Identifiers

PMID: 27526058
DOI: 10.1097/MPG.0000000000001375
PMCID: PMC5074882

Genes

ADD3
XPNPEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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