Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.

doi:10.1016/j.jhep.2023.07.039

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Article

Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.

Journal of hepatology - 1 Dec 2023

Glessner Joseph T, Ningappa Mylarappa B, Ngo Kim A, Zahid Maliha, So Juhoon, Higgs Brandon W, Sleiman Patrick M A, Narayanan Tejaswini, Ranganathan Sarangarajan, March Michael, Prasadan Krishna, Vaccaro Courtney, Reyes-Mugica Miguel, Velazquez Jeremy, Salgado Claudia M, Ebrahimkhani Mo R, Schmitt Lori, Rajasundaram Dhivyaa, Paul Morgan, Pellegrino Renata, Gittes George K, Li Dong, Wang Xiang, Billings Jonathan, Squires Robert, Ashokkumar Chethan, Sharif Khalid, Kelly Deirdre, Dhawan Anil, Horslen Simon, Lo Cecilia W, Shin Donghun, Subramaniam Shankar, Hakonarson Hakon, Sindhi Rakesh

Abstract excerpt

BACKGROUND & AIMS: Biliary atresia (BA) is poorly understood and leads to liver transplantation (LT), with the requirement for and associated risks of lifelong immunosuppression, in most children. We performed a genome-wide association study (GWAS) to determine the genetic basis of BA. METHODS: We performed a GWAS in 811 European BA cases treated with LT in US, Canadian and UK centers, and 4,654 genetically...

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PMID: 37572794
DOI: 10.1016/j.jhep.2023.07.039
PMCID: PMC10729795

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