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Article

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts.

Virology - 1 Nov 2016

Zhao Hanjun, Chu Hin, Zhao Xiaoyu, Shuai Huiping, Wong Bosco Ho-Yin, Wen Lei, Yuan Shuofeng, Zheng Bo-Jian, Zhou Jie, Yuen Kwok-Yung

Abstract excerpt

To evaluate the pathogenicity, a highly pathogenic avian influenza H7N7 virus (A/Netherlands/219/03) isolated from human was passaged in mice. A mutant virus (mH7N7) with attenuated virulence was isolated from mouse lung, which had a 3-log higher MLD50 than the wild-type virus (wH7N7). Sequence analysis and reverse genetics study revealed that mutations in PA account for the compromised viral replication in...

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PMID: 27525812
DOI: 10.1016/j.virol.2016.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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