Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.

Schizophrenia research - 1 Oct 2016

Chuang Yang-An, Hu Tsung-Ming, Chen Chia-Hsiang, Hsu Shih-Hsin, Tsai Hsin-Yao, Cheng Min-Chih

Abstract excerpt

Activity-regulated cytoskeleton-associated protein (ARC), which interacts with the N-methyl-d-aspartate receptor (NMDAR) complex, is a critical effector molecule downstream of multiple neuronal signaling pathways. Dysregulation of the ARC/NMDAR complex can disrupt learning, memory, and normal brain functions. This study examined the role of ARC in susceptibility to schizophrenia. We used a resequencing strategy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to CpG Islands
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Nerve Tissue Proteins

Share to Schizophrenia

Share to Taiwan

Source

Identifiers

PMID: 27464451
DOI: 10.1016/j.schres.2016.07.019

Genes

ARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.PMID 27464451Read ↗

Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channelsSemantic proximity Read ↗

De novo mutations in schizophrenia implicate synaptic networks.Semantic proximity Read ↗

A polygenic burden of rare disruptive mutations in schizophrenia.Semantic proximity Read ↗

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity.Semantic proximity Read ↗

Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE.Semantic proximity Read ↗

Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.Semantic proximity Read ↗

A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes.Semantic proximity Read ↗

Alteration of DNA Methylation and Epigenetic Scores Associated With Features of Schizophrenia and Common Variant Genetic RiskSemantic proximity Read ↗

Schizophrenia hiPSC neurons display expression changes that are enriched for disease risk variants and a blunted activity-dependent responseSemantic proximity Read ↗

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia.Semantic proximity Read ↗

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex FamiliesSemantic proximity Read ↗

Association of ARHGAP18 polymorphisms with schizophrenia in the Chinese-Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.