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Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

12 Aug 2016

Abstract excerpt

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barrier. However, whether increasing glucose transport into either of these cell types offers therapeutic potential remains unknown. Using an adult-onset Drosophila model of Aβ...

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PMID: 27524482
DOI: 10.1016/j.cub.2016.07.017

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