Article
Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010
Sarkar Mohan, Iliadi Konstantin G, Leventis Peter A, Schachter Harry, Boulianne Gabrielle L
Abstract excerpt
The enzyme UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnT1, encoded by Mgat1) controls the synthesis of paucimannose N-glycans in Drosophila. We have previously reported that null mutations in Drosophila Mgat1 are viable but exhibit defects in locomotion, brain abnormalities, and a severely reduced life span. Here, we show that knockdown of Mgat1 in the central nervous system (CNS)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.