Article
Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
The Journal of infectious diseases - 15 Oct 2016
Lüdtke Anja, Ruibal Paula, Becker-Ziaja Beate, Rottstegge Monika, Wozniak David M, Cabeza-Cabrerizo Mar, Thorenz Anja, Weller Romy, Kerber Romy, Idoyaga Juliana, Magassouba N'Faly, Gabriel Martin, Günther Stephan, Oestereich Lisa, Muñoz-Fontela César
Abstract excerpt
A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized...
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