Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System.

Abstract excerpt

Monocytes represent a heterogeneous population of primary immune effector cells. At least three different subsets can be distinguished based on expression of the low-affinity FcγRIII: CD14(++)CD16 -: classical monocytes, CD14(++)CD16(+) intermediate monocytes, and CD14(+)CD16 ++: non-classical monocytes. Whereas CD16 -: classical monocytes are considered key players in multiple sclerosis (MS), little is known on...

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• Autoimmune Diseases of the Nervous System
• Blood-Brain Barrier
• Central Nervous System
• Cerebrospinal Fluid
• Endothelial Cells