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Transcriptome Analysis of Circulating Immune Cell Subsets Highlight the Role of Monocytes in Zaire Ebola Virus Makona Pathogenesis

26 Oct 2017

Abstract excerpt

Existing models of Ebola virus disease (EVD) suggest antigen-presenting cells (APCs) are initial targets of Zaire ebolavirus (ZEBOV). In vitro studies have shown that ZEBOV infection of monocytes and macrophages results in the production of inflammatory mediators, which may cause lymphocyte apoptosis. However, these findings have not been corroborated by in vivo studies. In this study, we report the first...

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PMID: 29123522
DOI: 10.3389/fimmu.2017.01372

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