Article
Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodies.
Journal of Alzheimer's disease : JAD - 1 Jan 2021
van der Lee Sven J, van Steenoven Inger, van de Beek Marleen, Tesi Niccolò, Jansen Iris E, van Schoor Natasja M, Reinders Marcel J T, Huisman Martijn, Scheltens Philip, Teunissen Charlotte E, Holstege Henne, van der Flier Wiesje M, Lemstra Afina W
Abstract excerpt
BACKGROUND: Dementia with Lewy bodies (DLB) is a complex, progressive neurodegenerative disease with considerable phenotypic, pathological, and genetic heterogeneity. OBJECTIVE: We tested if genetic variants in part explain the heterogeneity in DLB. METHODS: We tested the effects of variants previously associated with DLB (near APOE, GBA, and SNCA) and polygenic risk scores for Alzheimer's disease (AD-PRS) and...
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