Article
FliW antagonizes CsrA RNA binding by a noncompetitive allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2016
Mukherjee Sampriti, Oshiro Reid T, Yakhnin Helen, Babitzke Paul, Kearns Daniel B
Abstract excerpt
CsrA (carbon storage regulator A) is a widely distributed bacterial RNA binding protein that regulates translation initiation and mRNA stability of target transcripts. In γ-proteobacteria, CsrA activity is competitively antagonized by one or more small RNAs (sRNAs) containing multiple CsrA binding sites, but CsrA in bacteria outside the γ-proteobacteria is antagonized by a protein called FliW. Here we show that...
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