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Article

Contact with the CsrA Core Is Required for Allosteric Inhibition by FliW in Bacillus subtilis.

Journal of bacteriology - 18 Dec 2020

Oshiro Reid T, Dunn Caroline M, Kearns Daniel B

Abstract excerpt

The RNA-binding protein CsrA is a posttranscriptional regulator encoded by genomes throughout the bacterial phylogeny. In the gammaproteobacteria, the activity of CsrA is inhibited by small RNAs that competitively sequester CsrA binding. In contrast, the firmicute Bacillus subtilis encodes a protein inhibitor of CsrA called FliW, which noncompetitively inhibits CsrA activity but for which the precise mechanism of...

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Identifiers

PMID: 33106347
DOI: 10.1128/JB.00574-20
PMCID: PMC7950408

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