Article
Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing.
Immunogenetics - 1 Nov 2016
Vasoya Deepali, Law Andy, Motta Paolo, Yu Mingyan, Muwonge Adrian, Cook Elizabeth, Li Xiaoying, Bryson Karen, MacCallam Amanda, Sitt Tatjana, Toye Philip, Bronsvoort Barend, Watson Mick, Morrison W Ivan, Connelley Timothy
Abstract excerpt
The major histocompatibility complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI and MHCII genes. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the variation that determines the nature of immune responses. Our current knowledge of the bovine MHCI repertoire is limited with only the...
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