Article
Fully Phased Population-Prevalent East African Cattle BoLA-I Alleles Determined Using PacBio HiFi Long-Read Sequencing Represent Five Novel Specificities With Distinctive Peptide Binding Potential.
HLA - 1 Apr 2025
Obara Isaiah, Sandro Andreotti, Elati Khawla, Conneley Timothy, Nielsen Morten, Githaka Naftaly, Nanteza Anne, Bishop Richard, Nijhof Ard
Abstract excerpt
Due to factors such as lower biosecurity, greater wildlife/farm animal interfaces, and environmental challenges, cattle in sub-Saharan Africa are exposed to more diverse and intensive bacterial, viral and protozoan pathogen challenges than cattle in Europe and other high-income regions of the world. Classical class I genes of the major histocompatibility complex (MHC) contribute to protection from diseases caused...
Read the complete abstract on PubMedTopics
- Animals
- Cattle
- Africa, Eastern
- Alleles
- CD8-Positive T-Lymphocytes
- High-Throughput Nucleotide Sequencing