Article
Highly-contiguous bovine genomes underpin accurate functional analyses and updated nomenclature of MHC class I.
HLA - 1 Mar 2022
Schwartz John C, Maccari Giuseppe, Heimeier Dorothea, Hammond John A
Abstract excerpt
The major histocompatibility complex (MHC) class I region of cattle is both highly polymorphic and, unlike many species, highly variable in gene content between haplotypes. Cattle MHC class I alleles were historically grouped by sequence similarity in the more conserved 3' end of the coding sequence to form phylogenetic allele groups. This has formed the basis of current cattle MHC class I nomenclature. We...
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