Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC.

doi:10.1158/1078-0432.CCR-11-0790

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Article

Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2011

Friboulet Luc, Barrios-Gonzales Daniel, Commo Frédéric, Olaussen Ken André, Vagner Stephan, Adam Julien, Goubar Aïcha, Dorvault Nicolas, Lazar Vladimir, Job Bastien, Besse Benjamin, Validire Pierre, Girard Philippe, Lacroix Ludovic, Hasmats Johanna, Dufour Fabienne, André Fabrice, Soria Jean-Charles

Abstract excerpt

PURPOSE: Excision repair cross-complementation group 1 (ERCC1) is a protein involved in repair of DNA platinum adducts and stalled DNA replication forks. We and others have previously shown the influence of ERCC1 expression upon survival rates and benefit of cisplatin-based chemotherapy in patients with resected non-small-cell lung cancer (NSCLC). However, little is known about the molecular characteristics of...

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PMID: 21750204
DOI: 10.1158/1078-0432.CCR-11-0790

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ERCC1

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