Article
Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism.
Molecular and cellular endocrinology - 5 Feb 2017
Tamura Ai, Nishimoto Koshiro, Seki Tsugio, Matsuzawa Yoko, Saito Jun, Omura Masao, Gomez-Sanchez Celso E, Makita Kohzoh, Matsui Seishi, Moriya Nobukazu, Inoue Atsushi, Nagata Maki, Sasano Hironobu, Nakamura Yasuhiro, Yamazaki Yuto, Kabe Yasuaki, Mukai Kuniaki, Kosaka Takeo, Oya Mototsugu, Suematsu Sachiko, Nishikawa Tetsuo
Abstract excerpt
We report a case of non-familial juvenile primary aldosteronism (PA). Super-selective adrenal venous sampling identified less aldosterone production in the right inferior adrenal segment than others. Bilateral adrenalectomy sparing the segment normalized blood pressure and improved PA. Both adrenals had similar histologies, consisting of a normal adrenal cortex and aldosterone synthase-positive...
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