Article
[Primary aldosteronism: new insights into familial forms].
Nederlands tijdschrift voor geneeskunde - 1 Jan 2015
van den Meiracker Anton H, van der Linde Annelieke A A, Claahsen van der Grinten Hedi L, Danser A H J Jan, Deinum Jaap
Abstract excerpt
Primary aldosteronism (PA) is characterized by autonomic aldosterone production, usually leading to severe hypertension and hypokalaemia. PA is a heterogeneous condition caused by sporadic adrenal adenoma, bilateral adrenal hyperplasia or rare familial forms. Familial aldosteronism type 1 is caused by a hybrid gene that codes for an ACTH-sensitive form of aldosterone synthase. Familial aldosteronism type 3 was...
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