Role of KCNJ5 in familial and sporadic primary aldosteronism.

Abstract excerpt

Primary aldosteronism is characterised by the dysregulation of aldosterone production and comprises both sporadic forms, caused by an aldosterone-producing adenoma or bilateral adrenal hyperplasia, and familial forms (familial hyperaldosteronism types I, II and III). The two principal physiological regulators of aldosterone synthesis are angiotensin II and serum K(+), which reverse the high resting K(+)...

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• Adrenal Glands
• Aldosterone
• G Protein-Coupled Inwardly-Rectifying Potassium Channels
• KCNJ5 gene
• Hyperaldosteronism