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Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease

10 Aug 2016

Abstract excerpt

Hydroxyurea (HU) has been used clinically to reduce the frequency of painful crisis and the need for blood transfusion in sickle cell disease (SCD) patients. However, the mechanisms underlying such beneficial effects of HU treatment are still not fully understood. Studies have indicated a weak correlation between clinical outcome and molecular markers, and the scientific quest to develop companion biophysical...

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PMID: 27512047
DOI: 10.1073/pnas.1610435113

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