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Article

Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies.

FEBS letters - 3 Jan 2014

Schipper-Krom Sabine, Juenemann Katrin, Jansen Anne H, Wiemhoefer Anne, van den Nieuwendijk Rianne, Smith Donna L, Hink Mark A, Bates Gillian P, Overkleeft Hermen, Ovaa Huib, Reits Eric

Abstract excerpt

Neurodegenerative disorders such as Huntington's disease are hallmarked by neuronal intracellular inclusion body formation. Whether proteasomes are irreversibly recruited into inclusion bodies in these protein misfolding disorders is a controversial subject. In addition, it has been proposed that the proteasomes may become clogged by the aggregated protein fragments, leading to impairment of the...

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PMID: 24291262
DOI: 10.1016/j.febslet.2013.11.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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