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Article

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model.

PloS one - 1 Jan 2015

Gabbita S Prasad, Johnson Ming F, Kobritz Naomi, Eslami Pirooz, Poteshkina Aleksandra, Varadarajan Sridhar, Turman John, Zemlan Frank, Harris-White Marni E

Abstract excerpt

Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammation can be perpetuated by a cycle of increasing cytokine production and maintenance of a polarized activation state that contributes to AD progression. In this study,...

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PMID: 26436670
DOI: 10.1371/journal.pone.0137305
PMCID: PMC4593589

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