Age-Stratified Meta-Transcriptomic Analysis Reveals Early and Core Dysregulated Pathways in Parkinson’s Disease

Abstract excerpt

Parkinson’s disease (PD) is strongly age-associated, yet how aging reshapes PD-related transcriptional changes remains unclear. We performed an age-stratified meta-analysis of 16 bulk RNA-seq datasets (646 samples: 314 PD, 332 controls) to distinguish early-onset (<60 years) from late-onset (≥60 years) signatures. In the full dataset, 131 significantly (padj<0.05, |log2FC|>1) differentially expressed genes (DEGs)...

Topics

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• Aging
• Autophagy in Disease and Therapy
• Gene Expression Profiling
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Multiomics
• Parkinson's Disease Mechanisms and Treatments
• RNA regulation and disease

Identifiers and source

Literature Corpus work

0096168c-14c1-5dd9-a185-6831be4b43f1

DOI

10.64898/2026.07.14.738591