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Article

The cellular phenotype conditions Btk for cell survival or apoptosis signaling.

Immunological reviews - 1 Dec 2000

Islam T C, Smith C I

Abstract excerpt

Bruton's agammaglobulinemia tyrosine kinase (Btk) was identified as the gene mutated in X-linked agammaglobulinemia. Btk is involved in B-cell receptor signaling and B cell ontogeny as the disease is characterized by a block in B-cell development. Cell proliferation and apoptosis are integral parts of B-cell development. We have demonstrated that overexpression of Btk in HeLa cells led to apoptosis, whereas in B...

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Identifiers

PMID: 11213806
DOI: 10.1034/j.1600-065x.2000.17811.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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