Article

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

2022-12-06

Abstract excerpt

<title>Abstract</title> <p>Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts. However, the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood. Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion. Single cell RNA sequ...

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Literature Corpus work: 91d8a501-08a8-57a1-ae92-450074f24569
DOI: 10.21203/rs.3.rs-2294200/v1

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