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Article

The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis.

Development (Cambridge, England) - 1 Jul 2007

Krieser Ronald J, Moore Finola E, Dresnek Douglas, Pellock Brett J, Patel Reena, Huang Albert, Brachmann Carrie, White Kristin

Abstract excerpt

Exposure of phosphatidylserine is a conserved feature of apoptotic cells and is thought to act as a signal for engulfment of the cell corpse. A putative receptor for phosphatidylserine (PSR) was previously identified in mammalian systems. This receptor is proposed to function in engulfment of apoptotic cells, although gene ablation of PSR has resulted in a variety of phenotypes. We examined the role of the...

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PMID: 17522160
DOI: 10.1242/dev.02860

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