Article
Oncogene-induced senescence: the bright and dark side of the response.
Current opinion in cell biology - 1 Dec 2010
Gorgoulis Vassilis G, Halazonetis Thanos D
Abstract excerpt
In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since then large leaps in understanding this phenomenon have been achieved. There is substantial evidence supporting oncogene-induced senescence (OIS) as a potent antitumor barrier in vivo. Multiple pathways participating in cell cycle regulation, DNA damage signaling, immune response, and bioenergetics regulate the process....
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