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bptA ( bbe16 ) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi , in its natural tick vector

28 Apr 2005

Abstract excerpt

Borrelia burgdorferi (Bb), the agent of Lyme disease, is a zoonotic spirochetal bacterium that depends on arthropod (Ixodes ticks) and mammalian (rodent) hosts for its persistence in nature. The quest to identify borrelial genes responsible for Bb's parasitic dependence on these two diverse hosts has been hampered by limitations in the ability to genetically manipulate virulent strains of Bb. Despite this...

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PMID: 15860579
DOI: 10.1073/pnas.0502565102

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