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The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens

21 Aug 2007

Abstract excerpt

The linear plasmid, lp28-1, is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. This plasmid contains the vls antigenic variation locus, which has long been thought to be important for immune evasion. However, the role of the vls locus as a virulence factor during mammalian infection has not been clearly defined. We report the successful removal of the vls locus through...

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PMID: 17714442
DOI: 10.1111/j.1365-2958.2007.05895.x

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The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensPMID 17714442Read ↗

Investigating the potential role of non-vls genes on linear plasmid 28-1 in virulence and persistence by Borrelia burgdorferi.Semantic proximity Read ↗

vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.Semantic proximity Read ↗

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.Semantic proximity Read ↗

Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1.Semantic proximity Read ↗

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogenSemantic proximity Read ↗

Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.Semantic proximity Read ↗

Variable VlsE is critical for host reinfection by the Lyme disease spirochete.Semantic proximity Read ↗

Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.Semantic proximity Read ↗

Changing of the guard: How the Lyme disease spirochete subverts the host immune response.Semantic proximity Read ↗

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.Semantic proximity Read ↗

Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi InfectionSemantic proximity Read ↗

Evidence That the Variable Regions of the Central Domain of VlsE Are Antigenic during Infection with Lyme Disease SpirochetesSemantic proximity Read ↗

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