Article
Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.
Cell - 18 Apr 1997
Zhang J R, Hardham J M, Barbour A G, Norris S J
Abstract excerpt
We have identified and characterized an elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promotes extensive antigenic variation of a surface-exposed lipoprotein, VlsE. A 28 kb linear plasmid of B. burgdorferi B31 (lp28-1) was found to contain a vmp-like sequence (...
Topics
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Proteins
- Base Sequence
- Borrelia burgdorferi Group
- Cloning, Molecular
- Female
- Genes, Bacterial
- Genetic Variation
- Lipoproteins
- Mice
- Mice, Inbred C3H
- Models, Genetic
- Molecular Sequence Data
- Plasmids