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Article

Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.

Cell - 18 Apr 1997

Zhang J R, Hardham J M, Barbour A G, Norris S J

Abstract excerpt

We have identified and characterized an elaborate genetic system in the Lyme disease spirochete Borrelia burgdorferi that promotes extensive antigenic variation of a surface-exposed lipoprotein, VlsE. A 28 kb linear plasmid of B. burgdorferi B31 (lp28-1) was found to contain a vmp-like sequence (vls) locus that closely resembles the variable major protein (vmp) system for antigenic variation of relapsing fever...

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PMID: 9108482
DOI: 10.1016/s0092-8674(00)80206-8

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Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes.PMID 9108482Read ↗

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Antigenic variation with a twist – the <i>Borrelia</i> storySemantic proximity Read ↗

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.Semantic proximity Read ↗

Evidence That the Variable Regions of the Central Domain of VlsE Are Antigenic during Infection with Lyme Disease SpirochetesSemantic proximity Read ↗

Breaking a barrier: In trans vlsE recombination and genetic manipulation of the native vlsE gene of the Lyme disease pathogenSemantic proximity Read ↗

The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogensSemantic proximity Read ↗

Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion.Semantic proximity Read ↗

Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi.Semantic proximity Read ↗

Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.Semantic proximity Read ↗

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