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Article

Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.

Infection and immunity - 1 Oct 2004

Grimm Dorothee, Eggers Christian H, Caimano Melissa J, Tilly Kit, Stewart Philip E, Elias Abdallah F, Radolf Justin D, Rosa Patricia A

Abstract excerpt

Borrelia burgdorferi, which causes Lyme disease in humans, has an unusual genome composed of a linear chromosome and up to 21 extrachromosomal elements. Experimental data suggest that two of these elements, linear plasmids lp25 and lp28-1, play essential roles for infectivity in mice. In this study, we prove the essential natures of these two plasmids by selectively displacing lp25 or lp28-1 in an infectious...

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Identifiers

PMID: 15385497
DOI: 10.1128/IAI.72.10.5938-5946.2004
PMCID: PMC517563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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