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Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes.

Carcinogenesis - 1 May 2010

Kohno Takashi, Kunitoh Hideo, Shimada Yoko, Shiraishi Kouya, Ishii Yuko, Goto Koichi, Ohe Yuichiro, Nishiwaki Yutaka, Kuchiba Aya, Yamamoto Seiichiro, Hirose Hiroshi, Oka Akira, Yanagitani Noriko, Saito Ryusei, Inoko Hidetoshi, Yokota Jun

Abstract excerpt

Adenocarcinoma (ADC) is the commonest histological type of lung cancer, and its weak association with smoking indicates the necessity to identify high-risk individuals for targeted screening and/or prevention. By a genome-wide association study (GWAS), we identified an association of polymorphisms in the 6p21.31 locus containing four human leukocyte antigen (HLA) class II genes with lung ADC risk. DQA1*03 of the...

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Identifiers

PMID: 20061363
DOI: 10.1093/carcin/bgq003

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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