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Adhere, Degrade, and Move: The Three-Step Model of Invasion

31 May 2016

Abstract excerpt

Experimental work during the period 1975-1986 revealed the crucial importance of the extracellular matrix (ECM) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion. The first step is tumor cell attachment to the ECM. The second step is proteolytic degradation of the ECM, led by advancing protruding actin-rich pseudopods. The third step is migration of the tumor cell body...

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PMID: 27251085
DOI: 10.1158/0008-5472.can-16-1297

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