Article
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
The Journal of clinical investigation - 1 Sept 2016
Cui Jing, Ding Yi, Chen Shu, Zhu Xiaoqiang, Wu Yichen, Zhang Mingliang, Zhao Yaxin, Li Tong-Ruei R, Sun Ling V, Zhao Shimin, Zhuang Yuan, Jia Weiping, Xue Lei, Han Min, Xu Tian, Wu Xiaohui
Abstract excerpt
A rise in the occurrence of obesity has driven exploration of its underlying genetic basis and potential targets for intervention. GWAS studies have identified obesity susceptibility pathways involving several neuropeptides that control energy homeostasis, suggesting that variations in the genes that regulate food intake and energy expenditure may contribute to obesity. In this study, we identified 5 additional...
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