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Article

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

PLoS pathogens - 1 Dec 2009

Lecordier Laurence, Vanhollebeke Benoit, Poelvoorde Philippe, Tebabi Patricia, Paturiaux-Hanocq Françoise, Andris Fabienne, Lins Laurence, Pays Etienne

Abstract excerpt

Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infect humans, causing sleeping sickness. In the case of T. b. rhodesiense, resistance to lysis involves interaction of the Serum Resistance-Associated (SRA) protein with...

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Identifiers

PMID: 19997494
DOI: 10.1371/journal.ppat.1000685
PMCID: PMC2778949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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