Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

15 May 2014

Abstract excerpt

Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause sleeping sickness in humans. T. b. brucei fails to infect humans because it is sensitive to innate immune complexes found in normal human serum known as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysosomal Storage Disorders Research
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24830321
DOI: 10.1371/journal.ppat.1004130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei bruceiPMID 24830321Read ↗

Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei.Semantic proximity Read ↗

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.Semantic proximity Read ↗

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genomeSemantic proximity Read ↗

Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum ResistanceSemantic proximity Read ↗

The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambienseSemantic proximity Read ↗

Mechanism of <i>Trypanosoma brucei gambiense</i> (group 1) resistance to human trypanosome lytic factorSemantic proximity Read ↗

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.Semantic proximity Read ↗

A <i>Trypanosoma brucei gambiense</i> gene variant confers human serum resistanceSemantic proximity Read ↗

Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factorsSemantic proximity Read ↗

Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1Semantic proximity Read ↗

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune SystemSemantic proximity Read ↗

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.