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Molecular Analysis of Luminal Androgen Receptor Reveals Activated Pathways and Potential Therapeutic Targets in Breast Cancer.

Cancer genomics & proteomics - 1 Jan 2000

Stella Stefania, Vitale Silvia Rita, Massimino Michele, Motta Gianmarco, Longhitano Claudio, Lanzafame Katia, Martorana Federica, Fazzari Carmine, Vecchio Giada Maria, Tirrò Elena, Inzerilli Nicola, Carciotto Rosaria, Manzella Livia, Caruso Michele, Vigneri Paolo

Abstract excerpt

BACKGROUND/AIM: Triple-negative breast cancers represent 15% of all mammary malignancies and encompass several entities with different genomic characteristics. Among these, luminal androgen receptor (LAR) tumors express the androgen receptor (AR) and are characterized by a genomic profile which resembles luminal breast cancers. Moreover, LAR malignancies are usually enriched in PIK3CA, KMTC, CDH, NF1, and AKT1...

Topics

Breast Neoplasms
Class I Phosphatidylinositol 3-Kinases
Female
Humans
Mutation
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Receptors, Androgen
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TOR Serine-Threonine Kinases

Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35732329
DOI: 10.21873/cgp.20333
PMCID: PMC9247873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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