Article
NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia.
Leukemia - 1 Jul 2024
Bonato Alice, Chakraborty Supriya, Bomben Riccardo, Canarutto Giulia, Felician Giulia, Martines Claudio, Zucchetto Antonella, Pozzo Federico, Vujovikj Marija, Polesel Jerry, Chiarenza Annalisa, Del Principe Maria Ilaria, Del Poeta Giovanni, D'Arena Giovanni, Marasca Roberto, Tafuri Agostino, Laurenti Luca, Piazza Silvano, Dimovski Aleksandar J, Gattei Valter, Efremov Dimitar G
Abstract excerpt
Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell malignancies and have been associated with accelerated disease progression and inferior responses to chemotherapy. Using in vitro and in vivo murine models and primary patient samples, we now show that NFKBIE-mutated CLL cells are selected by...
Topics
- Animals
- Humans
- Mice
- Adenine
- CD8-Positive T-Lymphocytes
- Leukemia, Lymphocytic, Chronic, B-Cell
- Mutation
- NF-kappa B
- Piperidines