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Article

Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma

3 Apr 2019

Abstract excerpt

BACKGROUND: Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when replication-defective vectors were used. We previously showed that a substantial fraction of herpes simplex virus thymidine kinase (HSV-TK) transduced tumor cells survive ganciclovir (GCV)...

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PMID: 30958558
DOI: 10.1093/neuonc/noz060

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