Article
Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.
Current gene therapy - 1 Feb 2003
Fillat C, Carrió M, Cascante A, Sangro B
Abstract excerpt
Gene-directed enzyme prodrug therapy (GDEPT) is a two step therapeutic approach for cancer gene therapy. In the first step, the transgene is delivered into the tumor and expressed. In the second step a prodrug is administered and is selectively activated by the expressed enzyme. The first GDEPT system described was the thymidine kinase gene of the Herpes Simplex virus (HSVtk) in combination with the prodrug...
Topics
- Cell Death
- Ganciclovir
- Genetic Therapy
- Genetic Vectors
- Humans
- Mutation
- Neoplasms
- Simplexvirus
- Thymidine Kinase