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Article

Herpes Vector-Mediated Gene Transfer in Treatment of Diseases of the Nervous System

1 Oct 2004

Abstract excerpt

Vectors constructed from recombinant herpes simplex virus (HSV) have special utility for gene transfer to the nervous system. Nonreplicating vectors created by deletion of essential immediate early genes can be propagated to high titers on complementing cell lines that provide the missing gene product(s) in trans. Direct inoculation of these vectors into neural parenchyma is effective in rodent models of brain...

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Identifiers

PMID: 15487938
DOI: 10.1146/annurev.micro.58.030603.123709

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