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Article

Lithium Restores Age-related Olfactory Impairment in the Ts65Dn Mouse Model of Down Syndrome.

CNS & neurological disorders drug targets - 1 Jan 2017

Guidi Sandra, Bianchi Patrizia, Stagni Fiorenza, Giacomini Andrea, Emili Marco, Trazzi Stefania, Ciani Elisabetta, Bartesaghi Renata

Abstract excerpt

BACKGROUND & OBJECTIVE: Down syndrome, a genetic condition caused by triplication of chromosome 21, is characterized by widespread neurogenesis reduction and cognitive impairment. Unlike other brain functions, smell is not impaired at early life stages and olfactory deterioration begins to appear in adulthood. Similarly to individuals with Down syndrome, in the Ts65Dn mouse model of Down syndrome smell function...

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Identifiers

PMID: 27488422
DOI: 10.2174/1871527315666160801143108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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